N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization

Abstract

Our study reveals that m1A regulation is significantly associated with the pathogenesis of human AAA. The m1A "reader," <i>YTHDF3</i>, may participate in the modulating of macrophage polarization that promotes aortic inflammation, and influence AAA progression by regulating the expression of its target genes.