Concepedia

Cattle Encephalon Glycoside and Ignotin Ameliorate Palmitoylation of PSD-95 and Enhance Expression of Synaptic Proteins in the Frontal Cortex of a APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Yinghan Zhang, Yazhuo Hu, Zhitao Han, Yan Geng, Zheng Xia, Yongsheng Zhou, Zhenfu Wang, Yuanyuan Wang, Eryan Kong, Xiaoning Wang,

Journal of Alzheimer s Disease · 2022 · 11 citations · 28 references

DOI

Abstract

Our findings demonstrate that CEGI improved AD-like neuropathology, possibly by inhibiting PSD-95 palmitoylation, improving learning memory, and enhancing expression of synaptic-associated proteins, representing a potential therapy for AD treatment.

References

28

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PSD-95 Involvement in Maturation of Excitatory Synapses

Alaa El-Husseini, Eric Schnell, Dane M. Chetkovich et al. · Science · 2000 · 1.3K citations

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Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

Eric Schnell, Max Sizemore, Siavash Karimzadegan et al. · Proceedings of the National Academy of Sciences · 2002 · 746 citations · Full text

Synaptic Strength Regulated by Palmitate Cycling on PSD-95

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Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach

Erika Bereczki, Rui M. Branca, Paul T. Francis et al. · Brain · 2017 · 226 citations · Full text