Proceedings of the National Academy of Sciences · 2022 · 49 citations · 64 references
Life SciencesNeurobiologyNeuroscienceNeurobiology Of DiseaseNeurodegenerationNeuroimmunologyMultiple System AtrophyNeurodegenerative DiseasesNeurodegenerative DisordersNeuroinflammationOligodendrocyte BiologyParkinson DiseaseAlpha-synuclein AggregationAlpha-synuclein MisfoldingAlpha-synuclein-targeted TherapyNeuroimmune Contributions To NeurodegenerationNeuroinflammation In Parkinson DiseaseOligodendrocyte ImmunityParkinson Disease NeuroimmunologyParkinson Disease Pathology
SignificanceOur results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy. The knowledge generated in this study could be used to devise novel therapeutic approaches to treat synucleinopathies.
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