Synthesis, biological evaluation and induced fit docking simulation study of<scp>d</scp>-glucose-conjugated 1<i>H</i>-1,2,3-triazoles having 4<i>H</i>-pyrano[2,3-<i>d</i>]pyrimidine ring as potential agents against bacteria and fungi

Abstract

Gluco-conjugated 1 H -1,2,3-triazoles having 4 H -pyrano[2,3- d ]pyrimidines are synthesized via click chemistry of N -propargyl-4 H -pyrano[2,3- d ]pyrimidines and glucopyaranosyl azide using CuI@Montmorillonite. Their antibacterial, anti-MRSA, and antifungal activity is probed.