Synthesis of functionalized 1-aminoisoquinolines through cascade three-component reaction of <i>ortho</i>-alkynylbenzaldoximes, 2<i>H</i>-azirines, and electrophiles

Abstract

-azirines, and ring-opening reaction sequences. The broad range of structurally diverse products, good to high yields, high atom-economy and high bond-formation efficiency make this method an attractive alternative for the synthesis of 1-aminoisoquinolines.