Acetogenins from Annonaceae plants: potent antitumor and neurotoxic compounds

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

Karsten Stamer, Robert Vogel, Edda Thies et al. · The Journal of Cell Biology · 2002 · 878 citations · Full text

Tau Blocks Traffic, Molecular Biology, Cytoskeleton +19

Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe

Pierre Champy, Günter U. Höglinger, Jean Féger et al. · Journal of Neurochemistry · 2003 · 250 citations · Full text

Annonacin, a Natural Mitochondrial Complex I Inhibitor, Causes Tau Pathology in Cultured Neurons

Myriam Escobar-Khondiker, Matthias Höllerhage, Marie‐Paule Muriel et al. · Journal of Neuroscience · 2007 · 201 citations · Full text

Cultured Neurons, Mitophagy, Nadh Oxidation +18

The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism

Annie Lannuzel, Patrick P. Michel, Günter U. Höglinger et al. · Neuroscience · 2003 · 165 citations

Mitophagy, Energy Metabolism, Mitochondrial Function +9

The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin

Letícia V. Costa‐Lotufo, Pablo Antônio Maia de Farias, Glauce Socorro de Barros Viana et al. · Toxicon · 2002 · 164 citations

Biochemistry, Medicine, Embryotoxic Effects +6