Alpha‐Ketoglutarate Attenuates Colitis in Mice by Increasing<i>Lactobacillus</i>Abundance and Regulating Stem Cell Proliferation via Wnt‐Hippo Signaling

Abstract

Collectively, the data provided herein demonstrate that α-KG administration is attenuated mucosal inflammation, barrier dysfunction, and gut microflora dysbiosis. This beneficial effect is associated with increased Lactobacillus levels and regulated colon hyperplasia by the Wnt-Hippo signaling pathway.