Study of Compounds Attached to Solid Supports Using High Resolution Magic Angle Spinning NMR

Abstract

This article presents an overview of high resolution magic angle spinning (HRMAS) NMR applied to solid phase synthesis. The different interactions existing in such samples are described and analyzed with respect to their effect on the linewidth of the sample. The critical element leading to the relatively narrow linewidth observed in such compounds using HRMAS is shown to be the averaging of the magnetic susceptibility differences at the resin bead I solvent interface. The hardware required to record such spectra is described with an emphasis on probe technology. Applications of HRMAS to a tetrapeptide, an organic molecule and a polymer are presented here.