Cultivated human intestinal fungus <i>Candida metapsilosis</i> M2006B attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists

Abstract

This study revealed that <i>C. metapsilosis</i> M2006B significantly attenuated colitis in mice and identified two acyclic sesquiterpenoids (F4 and F5) as major active metabolites of M2006B. Notably, these metabolites were able to effectively treat experimental colitis by selectively activating FXR. Together, this study demonstrates that M2006B could be a beneficial intestinal fungus for treating and preventing IBD.