Concepedia

Potassium <i>tert</i>-butoxide promoted regioselective deuteration of pyridines

Yan Li, Chenxu Zheng, Zhi‐Jiang Jiang, Jianbo Tang, Bencan Tang, Zhanghua Gao

Chemical Communications · 2022 · 48 citations · 26 references

DOI

Concepts

Abstract

, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.

References

26

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition‐Metal Complexes

Eric M. Simmons, John F. Hartwig · Angewandte Chemie International Edition · 2012 · 2.1K citations

, , +14

Using Deuterium in Drug Discovery: Leaving the Label in the Drug

Thomas G. Gant · Journal of Medicinal Chemistry · 2013 · 758 citations

, , +13

Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation

Sebastian Gisbertz, Susanne Reischauer, Bartholomäus Pieber · Nature Catalysis · 2020 · 249 citations

, , +9

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

J. Luke Koniarczyk, David Hesk, Alix Overgard et al. · Journal of the American Chemical Society · 2018 · 188 citations

, , +13

Regioselective and Stereospecific Deuteration of Bioactive Aza Compounds by the Use of Ruthenium Nanoparticles

Grégory Pieters, Céline Taglang, Eric Bonnefille et al. · Angewandte Chemie International Edition · 2013 · 176 citations

, , +12