The Journal of Infectious Diseases · 2022 · 28 citations · 10 references
Veterinary MedicineImmunologyInfectious DiseasesImmunizationImmunology Of Infectious DiseasesVaccinologyCell-mediated ImmunityCellular Immunity In InfectionImmune Response To VaccinationProtective ImmunityVaccinationViral VaccinesAntibody-dependent Cell-mediated CytotoxicityAntibody-dependent Cellular CytotoxicityCoronavirus VaccinesMechanisms Of Vaccine-induced ProtectionSars-cov-2 InfectionVaccination-induced Antibody ResponsesVaccine-induced Antibody Responses
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
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Proinflammatory IgG Fc structures in patients with severe COVID-19
Saborni Chakraborty, Joseph C. González, Karlie Edwards et al. · Nature Immunology · 2020 · 324 citations · Full text