Publication | Open Access
Comparison of Cellular Target Engagement Methods for the Tubulin Deacetylases Sirt2 and HDAC6: NanoBRET, CETSA, Tubulin Acetylation, and PROTACs
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Citations
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References
2022
Year
Small Molecule InhibitorsTubulin AcetylationMolecular BiologyTumor BiologyPotential Therapeutic AgentsBioanalysisAnti-cancer AgentProteomicsNovel TherapyProtein FunctionBiochemistryBiomolecular AnalysisTubulin Deacetylases Sirt2Cell BiologyProtein PhosphorylationBiomolecular EngineeringDrug TargetingSignal TransductionNatural SciencesVarious DiseasesTumor SuppressorCellular BiochemistryMedicineSmall MoleculesDrug Discovery
The tubulin deacetylases Sirt2 and HDAC6 have been associated with the development of various diseases. Herein, we discuss recent approaches that enable cellular target engagement studies for these deacetylases and thus play a critical role in the evaluation of small molecule inhibitors of Sirt2 or HDAC6 as potential therapeutic agents.
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