Can Glucose-Lowering Medications Improve Outcomes in Non-Diabetic Heart Failure Patients? A Bayesian Network Meta-Analysis

Abstract

This Bayesian network meta-analysis demonstrated that SGLT2i, when compared with GLP1-RA and metformin, was superior in improving LVEF in HF with reduced ejection fraction patients, as well as improving PVO₂ and NT-proBNP in non-diabetic HF patients. Further large-scale prospective studies are needed to confirm these preliminary findings.