Cigarette smoke extract mediates cell premature senescence in chronic obstructive pulmonary disease patients by up-regulating USP7 to activate p300-p53/p21 pathway

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Tumor Biology, Medicine, Rapid Degradation +6

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

Zhibin Wang, Chongzhi Zang, Kairong Cui et al. · Cell · 2009 · 1.3K citations · Full text

Natural Sciences, Genetics, Genome Structure +11

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

Steven R. Grossman, Maria E. Deato, Chrystelle Brignone et al. · Science · 2003 · 457 citations

Structure of the p53 Binding Domain of HAUSP/USP7 Bound to Epstein-Barr Nuclear Antigen 1

V. Saridakis, Yi Sheng, Feroz Sarkari et al. · Molecular Cell · 2005 · 349 citations · Full text

P53 Binding Domain, Protein Function, Immunology +8

USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer

Xiaomeng Dai, Lisen Lu, Suke Deng et al. · Theranostics · 2020 · 265 citations · Full text