Concepedia

Cytokines in the Immune Microenvironment Change the Glycosylation of IgG by Regulating Intracellular Glycosyltransferases

Yedi Cao, Zhijing Song, Zhendong Guo, Yan Gong, Keli Zhao, Chenxue Qu, Youyuan Huang, Yan Li, Ying Gao, Junqing Zhang,

Frontiers in Immunology · 2022 · 43 citations · 35 references

DOIFull text

Open access

Abstract

Abnormally elevated cytokines in the microenvironment regulates IgG glycan patterns by regulating intracellular glycosyltransferases in human B cells.

References

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A simple and rapid method for the permethylation of carbohydrates

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Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

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Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Mads Delbo Larsen, Erik L. de Graaf, Myrthe E. Sonneveld et al. · Science · 2020 · 396 citations · Full text

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Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

Margaret E. Ackerman, Max Crispin, Xiaojie Yu et al. · Journal of Clinical Investigation · 2013 · 353 citations · Full text

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Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

Gillian Dekkers, Louise W. Treffers, Rosina Plomp et al. · Frontiers in Immunology · 2017 · 349 citations · Full text