Concepedia

Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization

Chenfei Wang, Xiaobei Huang, Litao Sun, Qiuxia Li, Zhili Li, Haiyang Yong, Delu Che, Cong Yan, Songmei Geng, Wenxin Wang

Chemical Communications · 2022 · 26 citations · 17 references

DOI

Concepts

Abstract

sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.

References

17

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David M. Lynn, Róbert Langer · Journal of the American Chemical Society · 2000 · 913 citations

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A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

Jordan J. Green, Róbert Langer, Daniel G. Anderson · Accounts of Chemical Research · 2008 · 583 citations

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Synthesis of Poly(β-amino ester)s Optimized for Highly Effective Gene Delivery

Akin Akinc, Daniel G. Anderson, David M. Lynn et al. · Bioconjugate Chemistry · 2003 · 286 citations

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The Synthesis of Cyclic Poly(ethylene imine) and Exact Linear Analogues: An Evaluation of Gene Delivery Comparing Polymer Architectures

Mallory A. Cortez, W.T. Godbey, Yunlan Fang et al. · Journal of the American Chemical Society · 2015 · 225 citations

, , +16

The transition from linear to highly branched poly(β-amino ester)s: Branching matters for gene delivery

Dezhong Zhou, Lara Cutlar, Yongsheng Gao et al. · Science Advances · 2016 · 220 citations · Full text

, , +14