PCSK9 mediates dyslipidemia induced by olanzapine treatment in schizophrenia patients

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

Marianne Abifadel, Mathilde Varret, Jean‐Pierre Rabès et al. · Nature Genetics · 2003 · 3K citations

Life Sciences, Genetics, Molecular Genetics +10

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Jay D. Horton, Nila Shah, Janet A. Warrington et al. · Proceedings of the National Academy of Sciences · 2003 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9

Jonathan C. Cohen, Alexander Pertsemlidis, Ingrid K. Kotowski et al. · Nature Genetics · 2005 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +13

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking <i>Pcsk9</i>

Shirya Rashid, David E. Curtis, Rita Garuti et al. · Proceedings of the National Academy of Sciences · 2005 · 677 citations

Life Sciences, Molecular Biology, Pharmacology +17

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

Kara N. Maxwell, Jan L. Breslow · Proceedings of the National Academy of Sciences · 2004 · 612 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15