NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization

Abstract

Herein, we explored an unprecedented mild, nonirritating, conveniently available, and recyclable coupling reagent <b>NDTP</b>, which could activate the carboxylic acids via acyl thiocyanide and enable the rapid amide and peptide synthesis at very mild conditions. In addition, the methodology was compatible with Fmoc-SPPS, which may provide an alternative to peptide manufacturing.