Pragmatic Trials

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

The Lancet · 2002 · 7K citations

Medicine, Cardiology, Pharmacotherapy +13

A Randomized Trial of Intensive versus Standard Blood-Pressure Control

New England Journal of Medicine · 2015 · 6.2K citations · Full text

Medicine, Cardiology, Internal Medicine +15

Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial

Björn Dahlöf, Peter Sever, Neil R Poulter et al. · The Lancet · 2005 · 2.9K citations

Medicine, Cardiology, Pharmacology +10

External validity of randomised controlled trials: “To whom do the results of this trial apply?”

Peter M. Rothwell · The Lancet · 2005 · 2.5K citations

Public Health, Biostatistics, Evidence-based Practice +12

The PRECIS-2 tool: designing trials that are fit for purpose

Kirsty Loudon, Shaun Treweek, Frank Sullivan et al. · BMJ · 2015 · 1.8K citations · Full text

Public Health, Design, Evidence-based Practice +12