VX-765 prevents intestinal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu, Zhibin Zhang, Jianbin Ruan et al. · Nature · 2016 · 3.2K citations · Full text

Life Sciences, Cell Biology, Immunology +9

Intestinal Mucosal Lesion in Low-Flow States

Chu-Jeng Chiu · Archives of Surgery · 1970 · 1.8K citations

Life Sciences, Pathology, Physiology +17

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Lorenzo Sborgi, Sebastian Rühl, Estefania Mulvihill et al. · The EMBO Journal · 2016 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +7

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

Yifan Jia, Ruixia Cui, Cong Wang et al. · Redox Biology · 2020 · 328 citations · Full text

Life Sciences, Pathobiology, Pharmacology +17

(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R,3 S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

Woods Wannamaker, Robert M. D. Davies, Mark Namchuk et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 319 citations

Medicine, Medicinal Chemistry, Pharmacology +17