Concepedia

TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection

Yongjian Wu, Manni Wang, Huan Yin, Siqi Ming, Xingyu Li, Guanmin Jiang, Ye Liu, Pei‐Hui Wang, Guangde Zhou, Lei Liu,

Science Advances · 2021 · 47 citations · 62 references

DOIFull text

Open access

Concepts

Abstract

1 response and viral clearance, thus aggravating lung destruction. These findings demonstrate a previously unidentified role for TREM-2 in SARS-CoV-2 infection, and suggest potential strategies for drug discovery and clinical management of COVID-19.

References

62

Clinical Characteristics of Coronavirus Disease 2019 in China

Wei‐jie Guan, Zhengyi Ni, Yu Hu et al. · New England Journal of Medicine · 2020 · 31.2K citations · Full text

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, Hannah Kleine‐Weber, Simon Schroeder et al. · Cell · 2020 · 21.4K citations · Full text

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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

Zunyou Wu, Jennifer M. McGoogan · JAMA · 2020 · 18K citations · Full text

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Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Zhe Xu, Lei Shi, Yijin Wang et al. · The Lancet Respiratory Medicine · 2020 · 8.9K citations · Full text

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Virological assessment of hospitalized patients with COVID-2019

Roman Wölfel, Victor M. Corman, Wolfgang Guggemos et al. · Nature · 2020 · 7.2K citations · Full text

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