Concepedia

The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells

Nathália Azevedo Portilho, Deepak Saini, Ishtiaque Hossain, Jacinthe Sirois, Christopher Moraes, William A. Pastor

Epigenetics & Chromatin · 2021 · 63 citations · 32 references

DOIFull text

Open access

Abstract

GSK-3484862 mediates striking demethylation in mESCs with minimal non-specific toxicity.

References

32

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

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, , +13

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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Cellular differentiation, cytidine analogs and DNA methylation

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DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

David Roulois, Helen Loo Yau, Rajat Singhania et al. · Cell · 2015 · 1.4K citations · Full text

, , +10

KAP1 controls endogenous retroviruses in embryonic stem cells

Helen M. Rowe, Johan Jakobsson, Daniel Mesnard et al. · Nature · 2010 · 849 citations · Full text

, , +6