Biomaterials Science · 2021 · 19 citations · 30 references
Life SciencesBiochemistryMicrobiologyAntimicrobial ResistanceMicrobial PathogenesisRedox BiochemistryAntimicrobial ToxicityAntioxidant DefenseBioinorganic ChemistryIron HomeostasisIron MetabolismReactive Oxygen SpeciesAntimicrobial KillingDrug LipophilicityFe(ii) OxidationFenton ReactionIron BiochemistryIron CatalysisMicrobial Iron UptakeReactive Oxygen Species Generation
Iron—a double-edged sword in biology! The naturally-occuring lipophilic Fe( iii )-chelator hinokitiol allows for harnessing dysregulated iron uptake to kill Staphylococcus aureus bacteria.
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