Nimbolide-encapsulated PLGA nanoparticles induces Mesenchymal-to-Epithelial Transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Sendurai A. Mani, Wenjun Guo, Mai-Jing Liao et al. · Cell · 2008 · 8.6K citations · Full text

Regenerative Medicine, Epithelial-mesenchymal Transition, Developmental Biology +9

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

Mutant Braf, Raf/mek/erk Pathway, Medicine +12

Scalable molecular dynamics on CPU and GPU architectures with NAMD

J. C. Phillips, David J. Hardy, Julio D. C. Maia et al. · The Journal of Chemical Physics · 2020 · 3K citations · Full text

Engineering, Tailored Grids, Computer Architecture +22

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

Devon A. Lawson, Nirav R. Bhakta, Kai Kessenbrock et al. · Nature · 2015 · 906 citations · Full text

Human Cell, Breast Oncology, Single Cell Sequencing +10

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Jessica N. Spradlin, Xirui Hu, Carl C. Ward et al. · Nature Chemical Biology · 2019 · 404 citations

Drug Targeting, Health Sciences, Biochemistry +9