Concepedia

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

Ruben G.G. Leenders, Shoshy Alam Brinch, Sven T. Sowa, Enya Amundsen-Isaksen, Albert Galera‐Prat, Sudarshan Murthy, Sjoerd Aertssen, Johannes N. Smits, Piotr Nieczypor, Eddy Damen,

Journal of Medicinal Chemistry · 2021 · 23 citations · 41 references

DOIFull text

Open access

Concepts

Abstract

induced dose-dependent biomarker engagement and reduced cell growth in the colon cancer cell line COLO 320DM.

References

41

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31.4K citations · Full text

, , +17

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

, , +16

<i>XDS</i>

Wolfgang Kabsch · Acta Crystallographica Section D Biological Crystallography · 2010 · 16.9K citations · Full text

, , +13

<i>REFMAC</i>5 for the refinement of macromolecular crystal structures

Garib N. Murshudov, Pavol Skubák, Andrey A. Lebedev et al. · Acta Crystallographica Section D Biological Crystallography · 2011 · 8.7K citations · Full text

, , +17

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

, , +10