MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Mitja M. Zdouc, Kai Blin, Nico L L Louwen, +276

Nucleic Acids Research

EngineeringGeneticsMolecular BiologyGenomicsSecondary Metabolites +18

Elucidation of the biosynthesis of the methane catalyst coenzyme F430

Simon J. Moore, Sven T. Sowa, Christopher Schuchardt, +10

Nature

BiosynthesisEngineeringBiochemistryNatural SciencesBiocatalysis +5

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

Lilian C. Russo, Rebeka Tomasin, Isaac de Araújo Matos, +9

Journal of Biological Chemistry

Viral ReplicationSignal TransductionViral PathogenesisImmunologyMolecular Biology +6

A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases

Sven T. Sowa, Carlos Vela‐Rodríguez, Albert Galera‐Prat, +4

Scientific Reports

Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor

Jo Waaler, Ruben G.G. Leenders, Sven T. Sowa, +10

Journal of Medicinal Chemistry

A molecular toolbox for ADP-ribosyl binding proteins

Sven T. Sowa, Albert Galera‐Prat, Sarah Wazir, +3

Cell Reports Methods

Protein ChemistryProtein FunctionProtein AssemblyProtein FoldingNatural Sciences +5

Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II

Ruben G.G. Leenders, Shoshy Alam Brinch, Sven T. Sowa, +11

Journal of Medicinal Chemistry

[1,2,4]Triazolo[3,4- <i>b</i> ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes

Sudarshan Murthy, Maria Giulia Nizi, Mirko M. Maksimainen, +14

Journal of Medicinal Chemistry

The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models

Shoshy Alam Brinch, Enya Amundsen-Isaksen, Sandra Espada, +14

Cancer Research Communications

Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target

Sarah Wazir, Tomi A. O. Parviainen, Jessica J. Pfannenstiel, +9

Journal of Medicinal Chemistry