Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise et al. · Nature Methods · 2012 · 67.6K citations · Full text

Biology, Biological-image Analysis, Image Analysis +8

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.3K citations · Full text

Genome Instability, Novel Gene, Genetic Disorder +10

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Chiara Zuccato, Andrea Ciammola, Dorotea Rigamonti et al. · Science · 2001 · 1.3K citations

Neurodegenerative Diseases, Wild-type Huntingtin Activity, Bdnf Production +12

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

Sarah J. Tabrizi, Douglas R. Langbehn, Blair R. Leavitt et al. · The Lancet Neurology · 2009 · 959 citations

Neurodegenerative Diseases, Dementia, Longitudinal Track-hd Study +8

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

Kyung‐Ha Lee, Peipei Zhang, Hong Joo Kim et al. · Cell · 2016 · 703 citations · Full text

Biochemistry, Cell Organelle, Membrane-less Organelles +11