Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapy

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Leticia Corrales, Laura Hix Glickman, Sarah M. McWhirter et al. · Cell Reports · 2015 · 1.5K citations · Full text

Medicine, Immunology, Oncology +17

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

Bridget Larkin, Vladimir Ilyukha, Maxim Sorokin et al. · The Journal of Immunology · 2017 · 353 citations

Life Sciences, Cell Biology, Immunology +17

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response

Vijay K. Gonugunta, Tomomi Sakai, Vladislav Pokatayev et al. · Cell Reports · 2017 · 322 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis

Jun Li, Mercedes A. Duran Paez, Ninjit Dhanota et al. · Cancer Discovery · 2020 · 280 citations · Full text

Medicine, Cancer Biology, Oncology +17

Preliminary results of the first-in-human (FIH) study of MK-1454, an agonist of stimulator of interferon genes (STING), as monotherapy or in combination with pembrolizumab (pembro) in patients with advanced solid tumors or lymphomas

Kevin J. Harrington, Joshua Brody, M. Ingham et al. · Annals of Oncology · 2018 · 276 citations · Full text

Life Sciences, Immunology, Pharmacology +15