Concepedia

Oridonin inhibits SASP by blocking p38 and NF-κB pathways in senescent cells

Shusuke Yasuda, Mano Horinaka, Yosuke Iizumi, Wakana Goi, Mamiko Sukeno, Toshiyuki Sakai

Biochemical and Biophysical Research Communications · 2021 · 34 citations · 27 references

DOI

Concepts

References

27

A Restriction Point for Control of Normal Animal Cell Proliferation

Arthur B. Pardee · Proceedings of the National Academy of Sciences · 1974 · 1.4K citations · Full text

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p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype

Adam Freund, Christopher K. Patil, Judith Campisi · The EMBO Journal · 2011 · 1K citations · Full text

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p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling

Reut Yosef, Noam Pilpel, Nurit Papismadov et al. · The EMBO Journal · 2017 · 281 citations · Full text

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p21 produces a bioactive secretome that places stressed cells under immunosurveillance

Ines Sturmlechner, Cheng Zhang, Chance Sine et al. · Science · 2021 · 266 citations · Full text

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The role of p38 mitogen‐activated protein kinase in IL‐6 and IL‐8 production from the TNF‐α‐ or IL‐1β‐stimulated rheumatoid synovial fibroblasts

Masaki Suzuki, Toshifumi Tetsuka, Shin�ichi Yoshida et al. · FEBS Letters · 1999 · 202 citations · Full text

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