Concepedia

Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway

Zhimin Zha, Yujia Cheng, Lu Cao, Yanxia Qian, Xinjian Liu, Yan Guo, Junhong Wang

Journal of Inflammation Research · 2021 · 35 citations · 26 references

DOIFull text

Open access

Abstract

Taken together, our results imply that mCRP impairs myocardial repair after myocardial infarction by polarizing the macrophages into the pro-inflammatory M1 phenotype via the JNK-dependent pathway.

References

26

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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Macrophages are required for neonatal heart regeneration

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JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

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IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation

Mira Jung, Yonggang Ma, Rugmani Padmanabhan Iyer et al. · Basic Research in Cardiology · 2017 · 450 citations · Full text

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, , +14