HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non–Small Cell Lung Cancer

Abstract

Our findings help clarify the mechanisms of HER3 regulation in <i>EGFR</i>-mutated NSCLC tumors and highlight a rationale for combination therapy with HER3-DXd and EGFR-TKI in <i>EGFR</i>-mutated NSCLC.