Concepedia

Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis

Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

Journal of Oral Microbiology · 2021 · 21 citations · 33 references

DOIFull text

Open access

Abstract

MARK4 promoted NLRP3 inflammasome activation and pyroptosis in <i>P. gingivalis-</i>infected BMDMs by affecting microtubule dynamics. MARK4 inhibition might be a potential target in regulating the NLRP3 inflammasome during periodontitis progress.

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