Molecular Therapy — Nucleic Acids · 2021 · 83 citations · 31 references
MedicineNeuroscienceOncologyEndocytosisMolecular OncologyTumor MicroenvironmentBlood-brain Barrier DeliveryBrain Targeted DeliveryEndosomal EscapeGlioblastomaOligonucleotide DeliveryReceptor-mediated EndocytosisAntisense RnasAntitumor Immune ActivationEx Vivo DeliveryExosome-based TherapyExosomesExosomes In CancerScavenger Receptor-mediated UptakeTumor-derived Exosomes
with CpG-STAT3ASO inhibited subcutaneous tumor growth more effectively than the equivalent amount of oligonucleotide alone. Based on these results, we anticipate that NSCs and NSC-derived exosomes will provide a clinically relevant strategy to improve delivery and safety of oligonucleotide therapeutics for glioma treatment.
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Tumour exosome integrins determine organotropic metastasis
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
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Reassessment of Exosome Composition
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Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
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Life Sciences, Immunology, Oncology +14