TGFBR3L is an inhibin B co-receptor that regulates female fertility

Emilie Brûlé, Ying Wang, Yining Li, Yeu‐Farn Lin, Xiang Zhou, Luisina Ongaro, Carlos Agustín Isidro Alonso, Evan R. S. Buddle, Alan L. Schneyer, Chang‐Hyeock Byeon,

Science Advances · 2021 · 38 citations · 61 references

DOIFull text

Open access

Concepts

Abstract

knockout mice exhibit increased FSH levels, ovarian follicle development, and litter sizes. In contrast, female mice lacking both TGFBR3L and betaglycan are infertile. TGFBR3L’s function and cell-specific expression make it an attractive new target for the regulation of FSH and fertility.

References

61