Synthesis of functionalized 3,2′-pyrrolidinyl spirooxindoles <i>via</i> domino 1,6-addition/annulation reactions of <i>para</i>-quinone methides and 3-chlorooxindoles

Abstract

A highly efficient diastereoselective [4 + 1] cycloaddition of ortho -tosylaminophenyl-substituted p -QMs with 3-chlorooxindoles has been developed to afford 3,2′-pyrrolidinyl spirooxindoles.