Concepedia

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss

Olga Shubina-Oleinik, Carl Nist-Lund, Courtney E. French, Shira Rockowitz, A. Eliot Shearer, Jeffrey R. Holt

Science Advances · 2021 · 67 citations · 19 references

DOIFull text

Open access

Concepts

Abstract

Dual-AAV delivery to outer hair cells restores hearing in a mouse model of DFNB16, a common form of genetic hearing loss.

References

19

A framework for variation discovery and genotyping using next-generation DNA sequencing data

Mark A. DePristo, Eric Banks, Ryan Poplin et al. · Nature Genetics · 2011 · 12.4K citations · Full text

, , +14

Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss

Christina Sloan-Heggen, Amanda O. Bierer, A. Eliot Shearer et al. · Human Genetics · 2016 · 588 citations · Full text

, , +17

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

Jonathan M. Levy, Wei-Hsi Yeh, Nachiket Pendse et al. · Nature Biomedical Engineering · 2020 · 497 citations · Full text

, , +13

Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

Omar Akil, Rebecca P. Seal, Kevin Burke et al. · Neuron · 2012 · 396 citations · Full text

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<i>Tmc</i> gene therapy restores auditory function in deaf mice

Charles Askew, Cylia Rochat, Bifeng Pan et al. · Science Translational Medicine · 2015 · 256 citations · Full text

, , +17