Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Sharon E. Maynard, Jiang-Yong Min, Jaime R. Merchan et al. · Journal of Clinical Investigation · 2003 · 4K citations · Full text

Medicine, Maternal Health, Obstetrics +17

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

Hans-Peter Gerber, Amy E. McMurtrey, Joe Kowalski et al. · Journal of Biological Chemistry · 1998 · 2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Phase II, Randomized Trial Comparing Bevacizumab Plus Fluorouracil (FU)/Leucovorin (LV) With FU/LV Alone in Patients With Metastatic Colorectal Cancer

Fairooz F. Kabbinavar, Herbert I. Hurwitz, Louis Fehrenbacher et al. · Journal of Clinical Oncology · 2002 · 1.7K citations

Medicine, Oncology, Pharmacotherapy +13

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

Hans‐Peter Gerber, Fabrizio Condorelli, Jeanie Park et al. · Journal of Biological Chemistry · 1997 · 795 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

Yan Zhou, Michael McMaster, Kirstin Woo et al. · American Journal Of Pathology · 2002 · 644 citations · Full text

Public Health, Maternal Health, Obstetrics +17