p16INK4a Gene Promoter Hypermethylation in Mucosa as a Prognostic Factor for Patients with Colorectal Cancer

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Analytical Biochemistry · 1987 · 63.2K citations

Nucleic Acid Chemistry, Engineering, Natural Sciences +7

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Piotr Chomczyński, Nicoletta Sacchi · Analytical Biochemistry · 1987 · 46.8K citations

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Nonparametric Estimation from Incomplete Observations

Edward L. Kaplan, Paul Meier · Journal of the American Statistical Association · 1958 · 38.7K citations

Engineering, Aging, Life Prediction +21

MethyLight: a high-throughput assay to measure DNA methylation

Cindy A. Eads · Nucleic Acids Research · 2000 · 1.4K citations

Medicine, Genetics, Dna Methylation +12

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

James G. Herman, Adrian Merlo, Li Mao et al. · PubMed · 1995 · 1.4K citations

Epigenetic Change, Dna Methylation, Aberrant Dna Methylation +17