Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and <scp>l</scp>-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles

Abstract

In alloxan-diabetes in the rat, the uptake and oxidation of pyruvate by slices of ventricle muscle and by diaphragm muscle is impaired, and the output of lactate may be increased The cause of these abnormalities of pyruvate metabolism in diabetic muscle is not known. Newsholme & Randle (1964), Randle, Newsholme & Garland (1964) and Garland & Randle (1964a, b) have shown that two other abnormalities of carbohydrate metabolism in muscle from diabetic animals