In-vitro antimicrobial activity of bark extracts of an ethnic plant Zanthoxylum armatum DC. against selected human pathogens in Uttarakhand Himalaya.

Abstract

The present study is focused to evaluate the antimicrobial efficacy of Zanthoxylum armatum DC. (Rutaceae) against four different microorganisms viz Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Pseudomonas aeruginosa. Z. armatum is extensively used in indigenous system of medicine as a tonic, carminative, stomachic and antihelmintic. Present investigation is an attempt to reveal the antibacterial activity of the chloroform, methanol and acetone extracts of Z. armatum bark using the well diffusion method against four different bacterial strains. Highest ZOI was observed in acetone extract against S. aureus (42.3 mm) followed by methanolic extract against S. aureus (28.7mm) while highest chloroform extract against were found P .vulgaris (28.3 mm). Overall the methanol and acetone extract of bark was found to be more effective for S. aureus and chloroform extract for P. vulgaris. The results of the extracts were compared with the standard antibiotics.