Angiogenic synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in an<i>in vitro</i>quantitative microcarrier-based three-dimensional fibrin angiogenesis system

Abstract

A microcarrier-based in vitro three-dimensional angiogenesis model can be developed in fibrin. It offers a unique system for quantitative analysis of angiogenesis. Both bFGF and VEGF exert their angiogenic effects on HMVECs synergistically and in a dose-dependent manner.