Direct Catalytic Enantioselective α‐Aminoxylation of Ketones: A Stereoselective Synthesis of α‐Hydroxy and α,α′‐Dihydroxy Ketones

Abstract

Proline-catalyzed reactions between unmodified ketones and nitrosobenzene proceed with excellent diastereo- and enantioselectivities to provide protected α-hydroxy and α,α′-dihydroxy ketones [Eq. (1)]. Such compounds with chiral α-hydroxy carbonyl units are crucial in natural product synthesis.