Concepedia

Chemical synthesis, inhibitory activity and molecular mechanism of 1-deoxynojirimycin–chrysin as a potent α-glucosidase inhibitor

Ran Zhang, Yueyue Zhang, Gaiqun Huang, Xiangdong Xin, Liumei Tang, Hao Li, Kwang Sik Lee, Byung Rae Jin, Zhongzheng Gui

RSC Advances · 2021 · 18 citations · 29 references

DOIFull text

Open access

Concepts

Abstract

Hyperglycemia can be efficaciously regulated by inhibiting α-glucosidase activity and this is regarded as an effective strategy to treat type 2 diabetes.

References

29

α-glucosidase inhibitors from plants: A natural approach to treat diabetes

Vipin Kumar, Om Prakash, Sunil Kumar et al. · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · 2011 · 709 citations · Full text

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α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors

Hong Gao, Jun Kawabata · Bioorganic & Medicinal Chemistry · 2004 · 138 citations · Full text

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Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents

K. Suresh Babu, T. Hari Babu, Pullela V. Srinivas et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 130 citations

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A comparative study of flavonoid analogues on streptozotocin–nicotinamide induced diabetic rats: Quercetin as a potential antidiabetic agent acting via 11β-Hydroxysteroid dehydrogenase type 1 inhibition

Mariana Torres‐Piedra, Rolffy Ortíz‐Andrade, Rafael Villalobos‐Molina et al. · European Journal of Medicinal Chemistry · 2010 · 130 citations

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Synthesis, biological evaluation and molecular docking studies of chromone hydrazone derivatives as α-glucosidase inhibitors

Guangcheng Wang, Ming Chen, Jing Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 105 citations

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