Concepedia

A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6

Lu Wang, Jiahui Zhou, Chuan Zhang, Ranran Chen, Qingyang Sun, Peng Yang, Chaofan Peng, Yuqian Tan, Chi Jin, Tuo Wang,

Clinical and Translational Medicine · 2021 · 79 citations · 23 references

DOIFull text

Open access

Abstract

In summary, we reported for the first time that circMAPK14 functioned as a tumour-suppressor by encoding circMAPK14-175aa, which blocked the progression and metastasis of colorectal cancer.

References

23

Cancer statistics, 2019

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2019 · 20.7K citations · Full text

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Circular RNAs are a large class of animal RNAs with regulatory potency

Sebastian Memczak, Marvin Jens, Antigoni Elefsinioti et al. · Nature · 2013 · 8.3K citations

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Colorectal cancer statistics, 2017

Rebecca L. Siegel, Kimberly D. Miller, Stacey A. Fedewa et al. · CA A Cancer Journal for Clinicians · 2017 · 3.8K citations · Full text

, , +18

circRNA Biogenesis Competes with Pre-mRNA Splicing

Reut Ashwal-Fluss, Markus Meyer, Nagarjuna Reddy Pamudurti et al. · Molecular Cell · 2014 · 3.2K citations · Full text

, , +7

Extensive translation of circular RNAs driven by N6-methyladenosine

Yun Yang, Xiaojuan Fan, Miaowei Mao et al. · Cell Research · 2017 · 1.9K citations · Full text