Short‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation

Abstract

These results indicate that SCFAs produced by Ruminococcaceae mediate ALA promote ISCs proliferation by activating the Wnt/β-catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.