Concepedia

Synthesis of multi-substituted 1,2,4-triazoles utilising the ambiphilic reactivity of hydrazones

Haruo Matsuzaki, Norihiko Takeda, Motohiro Yasui, Mayuko Okazaki, Seishin Suzuki, Masafumi Ueda

Chemical Communications · 2021 · 17 citations · 43 references

DOI

Concepts

Abstract

-alkyl-triazoles in high yields. The synthetic utility of multi-substituted triazoles was also demonstrated by further transformations.

References

43

Hydrolytic Stability of Hydrazones and Oximes

Jeet Kalia, Ronald T. Raines · Angewandte Chemie International Edition · 2008 · 879 citations · Full text

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(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Dooseop Kim, Liping Wang, Maria Beconi et al. · Journal of Medicinal Chemistry · 2004 · 817 citations · Full text

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A Study of Dinitro-bis-1,2,4-triazole-1,1′-diol and Derivatives: Design of High-Performance Insensitive Energetic Materials by the Introduction of N-Oxides

Alexander A. Dippold, Thomas M. Klapötke · Journal of the American Chemical Society · 2013 · 432 citations

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The SAMP-/RAMP-hydrazone methodology in asymmetric synthesis

Andreas Job, Carsten F. Janeck, Wolfgang Bettray et al. · Tetrahedron · 2002 · 353 citations

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The CCR5 Receptor-Based Mechanism of Action of 873140, a Potent Allosteric Noncompetitive HIV Entry Inhibitor

Christian Watson, Stephen Jenkinson, Wieslaw M. Kazmierski et al. · Molecular Pharmacology · 2005 · 302 citations

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