Chemically Tuning the Antigen Release Kinetics from Spherical Nucleic Acids Maximizes Immune Stimulation

Kacper Skakuj, Michelle H. Teplensky, Shuya Wang, Jasper W. Dittmar, Chad A. Mirkin

ACS Central Science · 2021 · 31 citations · 27 references

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Abstract

, increasing the rate of antigen release resulted in higher T cell activation and target killing. These findings provide fundamental insights into and underscore the importance of vaccine structure.

References

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