Concepedia

Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells

Ruitu Lyu, Xuguo Zhu, Yinghui Shen, Lijun Xiong, Lu Liu, Hang Liu, Feizhen Wu, Christian Argueta, Li Tan

Epigenetics · 2021 · 15 citations · 41 references

DOIFull text

Open access

Concepts

Abstract

-associated genes through attenuating the binding of ERα. Taken together, these findings shed light on our understanding of the epigenetic mechanisms underlying the enhancer reprogramming during breast cancer pathogenesis.

References

41

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit et al. · International Journal of Cancer · 2014 · 29K citations · Full text

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RNA-Guided Human Genome Engineering via Cas9

Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.4K citations · Full text

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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Nathaniel D. Heintzman, Rhona Stuart, Gary C. Hon et al. · Nature Genetics · 2007 · 3.5K citations

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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

Yufei He, Bin-Zhong Li, Zheng Li et al. · Science · 2011 · 2.8K citations

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Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer

Balázs Győrffy · Computational and Structural Biotechnology Journal · 2021 · 1.7K citations · Full text

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