Concepedia

BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus

Huai‐Chia Chuang, Ming‐Han Chen, Yi‐Ming Chen, Huang‐Yu Yang, Yi‐Ru Ciou, Chia‐Hsin Hsueh, Ching‐Yi Tsai, Tse‐Hua Tan

Theranostics · 2021 · 45 citations · 34 references

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Concepts

Abstract

BPI is a negative regulator of Treg differentiation. BPI overexpression in T-cell-derived exosomes or peripheral blood T cells may be a biomarker and pathogenic factor for human SLE nephritis, hepatitis, and arthritis.

References

34

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Marı́a Mittelbrunn, Cristina Gutiérrez‐Vázquez, Carolina Villarroya‐Beltri et al. · Nature Communications · 2011 · 1.8K citations · Full text

, , +17

Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices

Ingeborg M. Bajema, Suzanne Wilhelmus, Charles E. Alpers et al. · Kidney International · 2018 · 1K citations · Full text

, , +10

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Hongyun Zhao, Lifeng Yang, Joelle Baddour et al. · eLife · 2016 · 924 citations · Full text

, , +17

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

Margaret Alexander, Ruozhen Hu, Marah C. Runtsch et al. · Nature Communications · 2015 · 767 citations · Full text

, , +17

Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes

Patricia A. Gonzales, Trairak Pisitkun, Jason D. Hoffert et al. · Journal of the American Society of Nephrology · 2008 · 728 citations

, , +17