Concepedia

TRPM2 Plays a Minor Role in AKI and Kidney Fibrosis

Yu Kurata, Tetsuhiro Tanaka, Hana Černecká, Frank Eitner, Masaomi Nangaku

Kidney360 · 2021 · 10 citations · 12 references

DOIFull text

Open access

Concepts

Abstract

-permeable cationic channel and serves as an oxidative stress sensor.TRPM2 deletion was harmful in renal ischemia-reperfusion injury, whereas TRPM2 deletion mitigated kidney fibrosis.Our findings suggest the role of TRPM2 in kidney diseases is context dependent.

References

12

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

Shinichiro Yamamoto, Shunichi Shimizu, Shigeki Kiyonaka et al. · Nature Medicine · 2008 · 622 citations · Full text

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Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels

Anne-Laure Perraud, Christina L. Takanishi, Betty Shen et al. · Journal of Biological Chemistry · 2004 · 362 citations · Full text

, , +13

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

Anke Di, Xiao-Pei Gao, Feng Qian et al. · Nature Immunology · 2011 · 239 citations · Full text

, , +14

C6 Mediates Chronic Progression of Tubulointerstitial Damage in Rats with Remnant Kidneys

Masaomi Nangaku, Jeffrey W. Pippin, William G. Couser · Journal of the American Society of Nephrology · 2002 · 127 citations

, , +14

TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1

Guofeng Gao, Weiwei Wang, Raghu Tadagavadi et al. · Journal of Clinical Investigation · 2014 · 127 citations

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